The Reds have already dropped points in four Premier League matches, almost half as many as in the entirety of last season, and cannot afford too many more slip-ups in Europe.
Ajax will believe they can cause a vulnerable Liverpool back-line real problems, after a classy win over Rangers that leaves them top of Group A after the opening match.
Here’s all you need to know about following the action tonight…
Where to watch Liverpool vs Ajax
TV channel: In the UK, tonight’s match will be televised live on BT Sport 2, with coverage beginning at 7pm BST ahead of an 8pm kick-off.
Live stream: BT Sport subscribers will also be able to watch the game online via the BT Sport website or app.